Clemson vs. Notre Dame prediction: Clemson favored to win men's college basketball matchup [1/10/2026]

Notre Dame will take on Clemson in men's college basketball action at Purcell Pavilion on Saturday, starting at 6:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Clemson as the most likely winner of the Clemson vs. Notre Dame game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Clemson vs. Notre Dame prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Clemson and Notre Dame 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Clemson a 64% chance of beating Notre Dame. Our predicted final score has Clemson winning 70-66.

According to our model, the bookmakers have got it right, and Clemson and Notre Dame each have a 50% chance of covering the spread, while the 133.5-point over/under has a 55% chance of going over.

Clemson vs. Notre Dame odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Clemson vs. Notre Dame picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: