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Clemson vs. Duke prediction: Duke favored to win men's college basketball matchup [2/14/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Clemson vs Duke predictions for college basketball Saturday.
Duke will take on Clemson in men's college basketball action at Cameron Indoor Stadium on Saturday, starting at 12:00 PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts Duke as the most likely winner of the Clemson vs. Duke game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Clemson vs. Duke prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Clemson and Duke 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model currently gives Duke an 89% chance of defeating Clemson. Our predicted final score has Duke winning 76-63.
According to our model, Duke (-12.5) has a 52% chance of covering the spread, while the over/under total of 134.5 points has a 58% chance of going over.
Clemson vs. Duke odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Clemson | Duke |
|---|---|---|
| Spread | +12.5 (-102) | -12.5 (-118) |
| Moneyline | +720 | -1100 |
| Total | o134.5 (-108) | u134.5 (-112) |
All odds are correct at the time of publication and are subject to change.
Clemson vs. Duke picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Clemson +12.5 | -102 |
| Moneyline | Clemson | +720 |
| Total | Over 134.5 | -108 |
According to our men's college basketball best bets, the top play to make on this game is Over 134.5 total points.
Clemson vs. Duke game-day updates and essential details
Saturday's men's college basketball matchup between Duke and Clemson at Cameron Indoor Stadium is scheduled to commence at 12:00 PM ET.
- Who: Clemson vs. Duke
- Date: Saturday, February 14, 2026
- Time: 12:00 PM ET/9:00AM PT
- Venue: Cameron Indoor Stadium
Conclusion
We predict Duke, with an 89% win probability, will likely beat Clemson on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Clemson vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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