Cincinnati vs. Clemson prediction: Why Clemson is favored to win men's college basketball matchup [12/21/2025]

Clemson will take on Cincinnati in men's college basketball action at Bon Secours Wellness Arena on Sunday, commencing at 3:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model projects Clemson as the most likely winner of the Cincinnati vs. Clemson game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Cincinnati vs. Clemson prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Sunday's NCAA basketball matchup between Cincinnati and Clemson 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Clemson a 70% chance of beating Cincinnati. Our predicted final score has Clemson winning 75-69.

According to our model, the bookmakers have got it right, and Cincinnati and Clemson each have a 50% chance of covering the spread, while the 141.5-point over/under has a 54% chance of going over.

Cincinnati vs. Clemson odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cincinnati vs. Clemson picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: