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Reds vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [5/30/2025]

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Written by Dave Garofolo

Our expert prediction for Friday's Cincinnati Reds vs Chicago Cubs matchup.

Cincinnati Reds-Chicago Cubs Predictions and Game Preview.
Wrigley Field sets the stage for the MLB matchup between the Cincinnati Reds and Chicago Cubs this Friday.

The Chicago Cubs will take on the Cincinnati Reds in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

Colin Rea (3-1, 3.28 ERA) will be on the bump for the Cubs, while the Reds are going with Andrew Abbott (4-0, 1.77 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cincinnati-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 59%, while the Reds' is 41%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Reds vs. Cubs predictions page.

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Cubs vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Reds and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 59% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Pre-Game Probabilities
Last Updated: 6:28PM, May 30
Moneyline
Over / Under
Run Line
Reds
Win %
41%
59%
Get the best bets with Dimers Pro
See Matchup
Cubs
Reds CIN
Win %
41%
59%
See Matchup
Cubs CHC
Andrew Abbott 4-0, 1.77 ERA
Colin Rea 3-1, 3.28 ERA
Get the best bets with Dimers Pro

Reds vs. Cubs Odds [5/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Reds Cubs
Run Line +1.5 (-150) -1.5 (+126)
Moneyline +140 -162
Total o9 (-114) u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Reds vs. Cubs matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Reds vs. Cubs Game-Day Updates and Essential Details

Friday's MLB action between the Cubs and Reds at Wrigley Field is scheduled to commence at 2:20PM ET.

Dimers.com's full preview of Friday's Reds vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Cubs, with a 59% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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