Cincinnati Bengals vs. Buffalo Bills updated prediction featuring Ja'Marr Chase, James Cook [Week 14, 2025]

Dimers' latest NFL predictions are live for Buffalo Bills vs. Cincinnati Bengals in Week 14, with our model giving the Bills a 65% of winning.

As Sunday approaches, both teams have updated their injury reports. A few lineup decisions are still up in the air, and those could shape how each side approaches this AFC clash.

Since our early Bills-Bengals predictions, we’ve updated the win probabilities, score projections, and TD odds for Ja'Marr Chase, James Cook, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—check out our Bengals vs. Bills page.

What's changed? Cincinnati vs. Buffalo updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Bengals vs. Bills matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Bengals 35%, Bills 65%
• Predicted Final Score: Bengals 24-28 Bills
• Spread: Bengals (+5.5) 54%, Bills (-5.5) 46%
• Total Points (53.5): Over 47%, Under 53%

As of December 4, 2025, these Bengals-Bills figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 14 highlight the top candidates to find the end zone in Bengals-Bills on Sunday:

Cincinnati Bengals

• Ja'Marr Chase: 47.5% probability
• Chase Brown: 45.1% probability
• Tee Higgins: 38.6% probability

Buffalo Bills

• James Cook: 57.4% probability
• Josh Allen: 53.0% probability
• Khalil Shakir: 30.0% probability

Bengals vs. Bills latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Bengals +5.5 (+100), Bills -5.5 (-110)
• Moneyline: Bengals +225, Bills -270
• Total: Over/Under 53.5 (-108/-108)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Bengals vs. Bills Week 14 details

The NFL Week 14 game between the Bills and Bengals at Highmark Stadium is scheduled for December 7, 2025.

• Who: Cincinnati Bengals vs. Buffalo Bills
• Date: Sunday, December 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

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Conclusion

We predict the Bills, with a 65% win probability, will likely beat the Bengals in Week 14 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bengals vs. Bills game, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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