Cincinnati Bengals vs. Buffalo Bills: Experts release early Week 14 predictions [2025]

The Cincinnati Bengals and Buffalo Bills will meet in Week 14 of the NFL season at Highmark Stadium on Sunday, December 7, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this AFC matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bengals vs. Bills predictions page.

Cincinnati vs. Buffalo early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bengals vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bengals 34%, Bills 66%
• Predicted final score: Bengals 23-28 Bills
• Spread: Bengals (+6) 56%, Bills (-6) 44%
• Total points (51.5): Over 50%, Under 50%

As of December 1, 2025, these Bengals-Bills numbers and predictions reflect the latest data and insights available.

Bengals vs. Bills Week 14 details

The NFL Week 14 game between the Bills and Bengals at Highmark Stadium is scheduled for December 7, 2025.

• Who: Cincinnati Bengals vs. Buffalo Bills
• Date: Sunday, December 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

Bengals vs. Bills opening odds

We've researched the best betting odds across America for this Week 14 game, which are listed here:

• Spread: Bengals +6 (-110), Bills -6 (-110)
• Moneyline: Bengals +225, Bills -270
• Total: Over/Under 51.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 14 highlight the top candidates to score a TD in Bengals-Bills in Week 14:

Cincinnati Bengals

• Ja'Marr Chase: 49.3% probability
• Chase Brown: 35.4% probability
• Andrei Iosivas: 26.8% probability

Buffalo Bills

• James Cook: 52.8% probability
• Josh Allen: 46.8% probability
• Khalil Shakir: 35.3% probability

Bengals vs Bills player props

Chase Brown is projected to lead rushing for the Bengals, while James Cook is expected to pace the Bills on the ground.

In the receiving game, our projections favor Cincinnati's Ja'Marr Chase and Buffalo's Khalil Shakir as the likely leaders for each team.

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Conclusion

We predict the Bills, with a 66% win probability, will likely beat the Bengals in Week 14 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bengals vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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