White Sox vs. Royals Prediction: Kansas City Predicted to Win Wednesday's MLB Matchup [5/7/2025]

The Kansas City Royals will take on the Chicago White Sox in MLB action at Kauffman Stadium on Wednesday, beginning at 7:40PM ET.

The Royals will start Michael Wacha (1-4, 3.52 ERA), while the White Sox are going with Jonathan Cannon (2-3, 4.26 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Royals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI White Sox-Kansas City game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Royals' chance of winning at 67%, with the White Sox at 33%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive White Sox vs. Royals predictions page.

Royals vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the White Sox and Royals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Royals a 67% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 53% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

White Sox vs. Royals Odds [5/7/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Royals
Run Line	+1.5 (-115)	-1.5 (-102)
Moneyline	+185	-218
Total	o8.5 (-104)	u8.5 (-118)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Royals Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Royals matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

White Sox vs. Royals Game-Day Updates and Essential Details

Wednesday's MLB game between the Royals and White Sox at Kauffman Stadium is scheduled to start at 7:40PM ET.

• Who: Chicago White Sox vs. Kansas City Royals
• Date: Wednesday, May 7, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Kauffman Stadium

Dimers.com's full preview of Wednesday's White Sox vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Kansas City picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Royals, with a 67% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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