Chicago State vs. Saint Louis prediction: Saint Louis favored to win men's college basketball matchup [11/6/2025]

Men's college basketball action continues on Thursday at 8:00PM ET as Chicago State takes on Saint Louis in men's college basketball action at Chaifetz Arena.

Based on updated simulations, Dimers' advanced college basketball model predicts Saint Louis as the most likely winner of the Chicago State vs. Saint Louis game.

This article offers an expanded analysis of Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Chicago State vs. Saint Louis prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Thursday's NCAA basketball game between Chicago State and Saint Louis 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Saint Louis a 98% chance of beating Chicago State. Our predicted final score has Saint Louis winning 90-63.

According to our model, Chicago State (+29.5) has a 54% chance of covering the spread, while the over/under total of 154.5 points has a 52% chance of staying under.

Chicago State vs. Saint Louis odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Chicago State vs. Saint Louis picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Chicago State +29.5 at the spread.

Chicago State vs. Saint Louis game-day updates and essential details

Thursday's men's college basketball matchup between Saint Louis and Chicago State at Chaifetz Arena is scheduled to begin at 8:00PM ET.

• Who: Chicago State vs. Saint Louis
• Date: Thursday, November 6, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Chaifetz Arena

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Conclusion

We predict Saint Louis, with a 98% win probability, will likely beat Chicago State on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Chicago State vs. Saint Louis insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Stay informed with the latest men's college basketball betting news and CBB parlay picks throughout the season. Plus, our NCAA Tournament Championship odds provide the most accurate probabilities for every March Madness contender.

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