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Cubs vs. Reds Prediction: Cubs Predicted to Win Sunday's MLB Matchup [5/25/2025]

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Written by Dave Garofolo

Our expert prediction for Sunday's Chicago Cubs vs Cincinnati Reds matchup.

Chicago Cubs-Cincinnati Reds Predictions and Game Preview.
Great American Ball Park sets the stage for the MLB matchup between the Chicago Cubs and Cincinnati Reds this Sunday.

The Cincinnati Reds and Chicago Cubs will lock horns in MLB action at Great American Ball Park on Sunday, starting at 1:40PM ET.

Nick Lodolo (4-4, 3.22 ERA) will start on the mound for the Reds, up against Ben Brown (3-3, 5.44 ERA) for the Cubs.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's CHI Cubs-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 56%, while the Reds have 44%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

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Reds vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB matchup between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 56% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 58% chance of covering the run line, while the 9-run over/under has a 56% chance of staying under.

Pre-Game Probabilities
Last Updated: 5:28PM, May 25
Moneyline
Over / Under
Run Line
Cubs
Win %
56%
44%
Get the best bets with Dimers Pro
See Matchup
Reds
Cubs CHC
Win %
56%
44%
See Matchup
Reds CIN
Ben Brown 3-3, 5.44 ERA
Nick Lodolo 4-4, 3.22 ERA
Get the best bets with Dimers Pro

Cubs vs. Reds Odds [5/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type Cubs Reds
Run Line -1.5 (+125) +1.5 (-142)
Moneyline -125 +114
Total o9 (-102) u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cubs vs. Reds Game-Day Updates and Essential Details

Sunday's MLB action between the Reds and Cubs at Great American Ball Park is scheduled to start at 1:40PM ET.

Dimers.com's comprehensive preview of Sunday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Cubs, with a 56% win probability, will likely beat the Reds on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date projections for the World Series, American League, National League and each division.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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