Cubs vs. Reds Prediction: Cubs Predicted to Win Friday's MLB Matchup [5/23/2025]

The Cincinnati Reds and Chicago Cubs will lock horns in MLB action at Great American Ball Park on Friday, starting at 6:40PM ET.

The Reds will start Hunter Greene (4-2, 2.36 ERA), while the Cubs will counter with Matthew Boyd (4-2, 2.98 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's CHI Cubs-Cincinnati game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 51%, while the Reds' is 49%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

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Reds vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 51% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 62% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:29PM, May 23

Moneyline

Over / Under

Run Line

Cubs

Win %

51%

49%

-108

+100

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Reds

Cubs CHC

-108

Win %

51%

49%

See Matchup

Reds CIN

+100

Matthew Boyd 4-2, 2.98 ERA

Hunter Greene 4-2, 2.37 ERA

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Cubs vs. Reds Odds [5/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Reds Game-Day Updates and Essential Details

Friday's MLB matchup between the Reds and Cubs at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Friday, May 23, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's in-depth preview of Friday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 51% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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