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Bears vs. 49ers prediction: San Francisco favored to win ‘SNF’ Week 17 [2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Chicago Bears vs San Francisco 49ers predictions for NFL Sunday.
The San Francisco 49ers and Chicago Bears will meet in Week 17 of the NFL season at Levi's Stadium on Sunday, with kickoff at 8:20 PM ET.
Based on the latest simulation results, Dimers' proven NFL model predicts the 49ers as the most likely winner of the Bears vs. 49ers game.
This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.
Bears vs. Niners prediction: Who will win ‘Sunday Night Football’?
Since our Bears-49ers predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Bears and 49ers 10,000 times as part of our NFL predictions coverage.
Our independent predictive model gives the 49ers a 62% chance of beating the Bears in Week 17 of the NFL season. Our predicted final score has the 49ers winning 27-24.
According to our model, the Bears (+4.5) have a 59% chance of covering the spread, while the over/under total of 51.5 points has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 17 straight up picks.
Bears vs. 49ers odds
We have researched the best NFL odds in America for this game, which are listed here:
| Bet Type | Bears | 49ers |
|---|---|---|
| Spread | +4.5 (-115) | -4.5 (-105) |
| Moneyline | +185 | -220 |
| Total | o51.5 (-108) | u51.5 (-112) |
All odds are correct at the time of publication and are subject to change.
Bears vs. 49ers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Bears +4.5 | -115 |
| Moneyline | Bears | +185 |
| Total | Over 51.5 | -108 |
According to our best NFL bets, the top play to make on this game is Bears +4.5 at the spread.
Bears vs. 49ers TD scorers
Who will score a touchdown in Bears vs. 49ers?
According to our list of touchdown scorer predictions for Week 17, Christian McCaffrey is most likely to score an anytime touchdown in Bears vs. 49ers.
Our projections give McCaffrey a 66.0% chance of scoring a TD at Levi's Stadium, while the running back is an 18.1% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Chicago Bears
| Player | Anytime TD Probability |
|---|---|
| D'Andre Swift (RB) | 37.9% |
| Kyle Monangai (RB) | 34.2% |
| DJ Moore (WR) | 30.7% |
| Colston Loveland (TE) | 27.6% |
| Luther Burden (WR) | 25.8% |
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 66.0% |
| Jauan Jennings (WR) | 39.3% |
| Ricky Pearsall (WR) | 28.2% |
| Jake Tonges (TE) | 21.1% |
| Brian Robinson (RB) | 17.3% |
First touchdown scorer predictions
Chicago Bears
| Player | First TD Probability |
|---|---|
| D'Andre Swift (RB) | 8.0% |
| Kyle Monangai (RB) | 7.0% |
| DJ Moore (WR) | 6.1% |
| Colston Loveland (TE) | 5.4% |
| Luther Burden (WR) | 5.0% |
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 18.1% |
| Jauan Jennings (WR) | 8.4% |
| Ricky Pearsall (WR) | 5.6% |
| Jake Tonges (TE) | 4.0% |
| Brian Robinson (RB) | 3.2% |
Bears vs 49ers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Bears and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 17 games.
Quarterbacks
Of the starting quarterbacks, the Bears' Caleb Williams is projected for 228 passing yards, while the 49ers' Brock Purdy is expected to throw for 257 yards.
| Player | Proj. Pass Yards |
|---|---|
| Caleb Williams (CHI) | 228 |
| Brock Purdy (SF) | 257 |
Bears rushing
| Player | Proj. Rush Yards |
|---|---|
| D'Andre Swift | 61 |
| Kyle Monangai | 47 |
| Caleb Williams | 23 |
49ers rushing
| Player | Proj. Rush Yards |
|---|---|
| Christian McCaffrey | 73 |
| Brian Robinson | 24 |
| Brock Purdy | 17 |
Bears receiving
| Player | Proj. Rec. Yards |
|---|---|
| Luther Burden | 57 |
| Colston Loveland | 44 |
| DJ Moore | 44 |
| Cole Kmet | 26 |
| Jahdae Walker | 19 |
49ers receiving
| Player | Proj. Rec. Yards |
|---|---|
| Jauan Jennings | 60 |
| Christian McCaffrey | 48 |
| Ricky Pearsall | 45 |
| Jake Tonges | 34 |
| Kendrick Bourne | 21 |
Bears vs. Niners game-day updates and essential details
The NFL Week 17 game between the 49ers and Bears at Levi's Stadium is scheduled to start at 8:20 PM ET.
- Who: Chicago Bears vs. San Francisco 49ers
- Date: Sunday, December 28, 2025
- Time: 8:20 PM ET/5:20PM PT
- Venue: Levi's Stadium
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Conclusion
We predict the 49ers, with a 62% win probability, will likely beat the Bears in Week 17 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Bears vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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