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Panthers vs. Saints prediction: Carolina favored to win in NFL Week 15 [2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Carolina Panthers vs New Orleans Saints predictions for NFL Sunday.
The New Orleans Saints and Carolina Panthers are scheduled to meet in Week 15 of the NFL season at Caesars Superdome on Sunday, with kickoff at 4:25PM ET.
Based on the latest simulation results, Dimers' proven NFL model projects the Panthers as the most likely winner of the Panthers vs. Saints game.
This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.
Panthers vs. Saints prediction: Who will win and cover?
Since our Panthers-Saints predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Panthers and Saints 10,000 times as part of our NFL predictions coverage.
Our famous predictive model currently gives the Panthers a 59% chance of beating the Saints in Week 15 of the NFL season. Our predicted final score has the Panthers winning 21-19.
According to our model, the bookmakers have got it right, and the Panthers and Saints each have a 50% chance of covering the spread, while the over/under total of 41 points has a 52% chance of going over.
To see win probabilities for every matchup this week, check out our expert NFL Week 15 straight up picks.
Panthers vs. Saints odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Panthers | Saints |
|---|---|---|
| Spread | -2.5 (-115) | +2.5 (+100) |
| Moneyline | -146 | +130 |
| Total | o41 (-110) | u41 (-110) |
All odds are correct at the time of publication and are subject to change.
Panthers vs. Saints picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Saints +2.5 | +100 |
| Moneyline | Panthers | -146 |
| Total | Over 41 | -110 |
According to our NFL best bets, the top play to make on this game is Saints +2.5 at the spread.
Panthers vs. Saints TD scorers
Who will score a touchdown in Panthers vs. Saints?
According to our list of touchdown scorer predictions for Week 15, Tetairoa McMillan is most likely to score an anytime touchdown in Panthers vs. Saints.
Our projections give McMillan a 34.6% chance of scoring a TD at Caesars Superdome, while the wide receiver is a 9.3% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Carolina Panthers
| Player | Anytime TD Probability |
|---|---|
| Tetairoa McMillan (WR) | 34.6% |
| Rico Dowdle (RB) | 33.6% |
| Chuba Hubbard (RB) | 25.9% |
| Jalen Coker (WR) | 20.5% |
| Xavier Legette (WR) | 20.4% |
New Orleans Saints
| Player | Anytime TD Probability |
|---|---|
| Devin Neal (RB) | 34.0% |
| Chris Olave (WR) | 31.6% |
| Devaughn Vele (WR) | 24.7% |
| Juwan Johnson (TE) | 23.3% |
| Taysom Hill (TE) | 18.2% |
First touchdown scorer predictions
Carolina Panthers
| Player | First TD Probability |
|---|---|
| Tetairoa McMillan (WR) | 9.3% |
| Rico Dowdle (RB) | 9.0% |
| Chuba Hubbard (RB) | 6.6% |
| Jalen Coker (WR) | 5.1% |
| Xavier Legette (WR) | 5.0% |
New Orleans Saints
| Player | First TD Probability |
|---|---|
| Devin Neal (RB) | 8.4% |
| Chris Olave (WR) | 7.7% |
| Devaughn Vele (WR) | 5.7% |
| Juwan Johnson (TE) | 5.4% |
| Taysom Hill (TE) | 4.1% |
Panthers vs Saints player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and Saints. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 15 games.
Quarterbacks
Of the starting quarterbacks, the Panthers' Bryce Young is projected for 200 passing yards, while the Saints' Tyler Shough is expected to throw for 215 yards.
| Player | Proj. Pass Yards |
|---|---|
| Bryce Young (CAR) | 200 |
| Tyler Shough (NO) | 215 |
Panthers rushing
| Player | Proj. Rush Yards |
|---|---|
| Rico Dowdle | 57 |
| Chuba Hubbard | 47 |
| Bryce Young | 12 |
Saints rushing
| Player | Proj. Rush Yards |
|---|---|
| Devin Neal | 59 |
| Tyler Shough | 21 |
| Audric Estime | 14 |
Panthers receiving
| Player | Proj. Rec. Yards |
|---|---|
| Tetairoa McMillan | 62 |
| Jalen Coker | 39 |
| Xavier Legette | 27 |
| Ja'Tavion Sanders | 18 |
| Chuba Hubbard | 15 |
Saints receiving
| Player | Proj. Rec. Yards |
|---|---|
| Chris Olave | 65 |
| Juwan Johnson | 41 |
| Devaughn Vele | 41 |
| Mason Tipton | 22 |
| Devin Neal | 19 |
Panthers vs. Saints game-day updates and essential details
The NFL Week 15 game between the Saints and Panthers at Caesars Superdome is scheduled to begin at 4:25PM ET.
- Who: Carolina Panthers vs. New Orleans Saints
- Date: Sunday, December 14, 2025
- Time: 4:25PM ET/1:25PM PT
- Venue: Caesars Superdome
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Conclusion
We predict the Panthers, with a 59% win probability, will likely beat the Saints in Week 15 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Saints insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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