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Cardinals vs. Guardians Prediction for MLB Saturday [5/27/2023]

The Cleveland Guardians face the St. Louis Cardinals in MLB action at Progressive Field on Saturday, starting at 7:15PM ET.

The Guardians will send Tanner Bibee (1-1, 3.18 ERA) to the mound, while the Cardinals are going with Jack Flaherty (3-4, 5.29 ERA).

Dimers' best betting picks for Cardinals vs. Guardians, plus game predictions and betting odds, are detailed in this article.


Who Will Win: Cardinals vs. Guardians

Using cutting-edge machine learning and data, Dimers.com has simulated Saturday's Cardinals-Guardians MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Cardinals a 51% chance of defeating the Guardians.

More: Betting Analysis for Cardinals vs. Guardians

Cardinals vs. Guardians Current Odds

  • Run Line: Guardians +1.5 (-170), Cardinals -1.5 (+155)
  • Moneyline: Guardians -102, Cardinals -110
  • Total: Over/Under 8.5 (+100/-120)

Run Line, Moneyline and Over/Under

The Guardians are currently +1.5 underdogs against the Cardinals, with -170 at FanDuel Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +155.

In a sign of how close this game is expected to be, both the Guardians and Cardinals are currently at minus-money betting odds on the moneyline.

FanDuel Sportsbook currently has the best moneyline odds for the Guardians at -102, which means you can risk $102 to win $100, for a total payout of $202, if they get the W.

Meanwhile, PointsBet currently has the best moneyline odds for the Cardinals at -110, where you can risk $110 to win $100, for a total payout of $210, if they come out on top.

The Over/Under for total runs scored sits at 8.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) have a 61% chance of covering the run line, while the Over/Under total of 8.5 runs has a 51% chance of going Over.

More: Best Free Bet Tracker

Best Bets for Cardinals vs. Guardians


Our best bets are based on world-class simulations and gambling expertise to bring you the best possible plays 24/7/365.

Although the Guardians are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

Cardinals vs. Guardians Probabilities

Click or tap on See Matchup for more.


Dimers has full coverage of Saturday's Cardinals-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this page for the latest betting insights before Cardinals vs. Guardians on Saturday May 27, 2023.


Cardinals vs. Guardians 2023

Saturday's action between the Guardians and Cardinals at Progressive Field is scheduled to commence at 7:15PM ET.

  • Who: St. Louis Cardinals vs. Cleveland Guardians
  • Date: Saturday May 27, 2023
  • Time: 7:15PM ET / 4:15PM PT
  • Venue: Progressive Field

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Calling Our Shot ⚾️ Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Make Smarter Sports Betting Decisions with Dimers

Dimers' picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While our Cardinals vs. Guardians picks can help you make informed decisions, it's vital that you only bet what you can afford to lose and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What Other MLB Games Are on Today?

The Cardinals and Guardians aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB matchup via our MLB Predictions page.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

In addition to MLB picks and predictions, Dimers also offers the best MLB prop bets for today, projecting home runs, RBIs, and more against the best odds available every day of the MLB season.

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the World Series, with our data-led probabilities paired with the best odds available.

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