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Cal Poly vs. USC prediction: USC favored to win men's college basketball matchup [11/3/2025]
Get Cal Poly vs USC predictions for college basketball Monday.

USC will take on Cal Poly in men's college basketball opening night action at Galen Center on Monday, commencing at 9:30PM ET.
Based on updated simulation results, Dimers' advanced college basketball model predicts the USC as the most likely winner of the Cal Poly vs. USC game.
This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and picks.
Cal Poly vs. USC prediction: Who will win, cover the spread?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Monday's NCAA basketball game between Cal Poly and USC 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives USC a 97% chance of beating Cal Poly. Our predicted final score has USC winning 91-67.
According to our model, Cal Poly (+24.5) has a 52% chance of covering the spread, while the 163.5-point over/under has a 54% chance of staying under.
Cal Poly vs. USC odds
We have sourced the best college basketball odds in America for this game, which are listed here:
| Bet Type | Cal Poly | USC |
|---|---|---|
| Spread | +24.5 (-110) | -24.5 (-110) |
| Moneyline | +2500 | -9001 |
| Total | o163.5 (-115) | u163.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Cal Poly vs. USC picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Cal Poly +24.5 | -110 |
| Moneyline | Cal Poly | +2500 |
| Total | Under 163.5 | -105 |
According to our best men's college basketball bets, the top play to make on this game is Under 163.5 total points.
Cal Poly vs. USC game-day updates and essential details
Monday's men's college basketball action between USC and Cal Poly at Galen Center is scheduled to begin at 9:30PM ET.
- Who: Cal Poly vs. USC
- Date: Monday, November 3, 2025
- Time: 9:30PM ET/6:30PM PT
- Venue: Galen Center
Conclusion
We predict USC, with a 97% win probability, will likely beat Cal Poly on Monday.
AI and automation have enhanced this article to quickly deliver accurate Cal Poly vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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