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Cal Poly vs. USC prediction: USC favored to win men's college basketball matchup [11/3/2025]

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Written by Mac Douglass

Get Cal Poly vs USC predictions for college basketball Monday.

Cal Poly-USC Predictions and Game Preview.
Cal Poly vs. USC men's college basketball prediction for Monday, November 3, 2025.

USC will take on Cal Poly in men's college basketball opening night action at Galen Center on Monday, commencing at 9:30PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts the USC as the most likely winner of the Cal Poly vs. USC game.

This article offers a closer look at Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Cal Poly vs. USC prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Monday's NCAA basketball game between Cal Poly and USC 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives USC a 97% chance of beating Cal Poly. Our predicted final score has USC winning 91-67.

According to our model, Cal Poly (+24.5) has a 52% chance of covering the spread, while the 163.5-point over/under has a 54% chance of staying under.

 

Cal Poly vs. USC odds

We have sourced the best college basketball odds in America for this game, which are listed here:

Bet Type Cal Poly USC
Spread +24.5 (-110) -24.5 (-110)
Moneyline +2500 -9001
Total o163.5 (-115) u163.5 (-105)

All odds are correct at the time of publication and are subject to change.

Cal Poly vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Cal Poly +24.5 -110
Moneyline Cal Poly +2500
Total Under 163.5 -105

According to our best men's college basketball bets, the top play to make on this game is Under 163.5 total points.

 

Cal Poly vs. USC game-day updates and essential details

Monday's men's college basketball action between USC and Cal Poly at Galen Center is scheduled to begin at 9:30PM ET.

  • Who: Cal Poly vs. USC
  • Date: Monday, November 3, 2025
  • Time: 9:30PM ET/6:30PM PT
  • Venue: Galen Center

Conclusion

We predict USC, with a 97% win probability, will likely beat Cal Poly on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cal Poly vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on men's college basketball

Stay up-to-date with the latest men's college basketball news and CBB parlay picks throughout the season. Plus, our NCAA Tournament Championship odds provide the latest predictions for every March Madness contender.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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