Butler vs. St. John's prediction: St. John's favored to win men's college basketball matchup [1/28/2026]

St. John's and Butler are scheduled to meet in men's college basketball action at Madison Square Garden on Wednesday, with tipoff at 7:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects St. John's as the most likely winner of the Butler vs. St. John's game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Butler vs. St. John's prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Butler and St. John's 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives St. John's an 88% chance of defeating Butler. Our predicted final score has St. John's winning 86-72.

According to our model, St. John's (-12.5) has a 56% chance of covering the spread, while the 158.5-point over/under has a 53% chance of staying under.

Butler vs. St. John's odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Butler vs. St. John's picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is St. John's -12.5 at the spread.

Butler vs. St. John's game-day updates and essential details

Wednesday's men's college basketball action between St. John's and Butler at Madison Square Garden is scheduled to begin at 7:00 PM ET.

• Who: Butler vs. St. John's
• Date: Wednesday, January 28, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Madison Square Garden

Conclusion

We predict St. John's, with an 88% win probability, will likely beat Butler on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Butler vs. St. John's insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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