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Buffalo vs. DePaul prediction: DePaul favored to win men's college basketball matchup [11/11/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Buffalo vs DePaul predictions for college basketball Tuesday.
DePaul will take on Buffalo in men's college basketball action at Wintrust Arena on Tuesday, commencing at 8:00PM ET.
Based on the latest simulation results, Dimers' proven college basketball model projects DePaul as the most likely winner of the Buffalo vs. DePaul game.
This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
Buffalo vs. DePaul prediction: Who will win, cover the spread?
Using trusted machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball game between Buffalo and DePaul 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives DePaul a 95% chance of defeating Buffalo. Our predicted final score has DePaul winning 85-65.
According to our model, DePaul (-18.5) has a 52% chance of covering the spread, while the over/under total of 153.5 points has a 53% chance of staying under.
Buffalo vs. DePaul odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Buffalo | DePaul |
|---|---|---|
| Spread | +18.5 (-105) | -18.5 (-110) |
| Moneyline | +1800 | -3000 |
| Total | o153.5 (-110) | u153.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Buffalo vs. DePaul picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul -18.5 | -110 |
| Moneyline | Buffalo | +1800 |
| Total | Under 153.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Under 153.5 total points.
Buffalo vs. DePaul game-day updates and essential details
Tuesday's men's college basketball matchup between DePaul and Buffalo at Wintrust Arena is scheduled to commence at 8:00PM ET.
- Who: Buffalo vs. DePaul
- Date: Tuesday, November 11, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: Wintrust Arena
Conclusion
We predict DePaul, with a 95% win probability, will likely beat Buffalo on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Buffalo vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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