Buffalo Bills vs. Miami Dolphins updated prediction featuring James Cook, De'Von Achane [Week 10, 2025]

Dimers' latest NFL predictions are live for Miami Dolphins and Buffalo Bills in Week 10, with our model giving the Bills a 78% of winning against the Dolphins on Sunday.

This update builds on our early Dolphins-Bills predictions, adding fresh win probabilities, score projections, and TD predictions for James Cook, De'Von Achane, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Bills vs. Dolphins page.

What's changed? Buffalo vs. Miami updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Bills vs. Dolphins matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Bills 78%, Dolphins 22%
• Predicted Final Score: Bills 28-20 Dolphins
• Spread: Bills (-9.5) 47%, Dolphins (+9.5) 53%
• Total Points (49.5): Over 47%, Under 53%

As of November 6, 2025, these Bills-Dolphins figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 10 highlight the top candidates to find the end zone in Bills-Dolphins on Sunday:

Buffalo Bills

• James Cook: 55.7% probability
• Josh Allen: 47.8% probability
• Khalil Shakir: 32.2% probability

Miami Dolphins

• De'Von Achane: 51.4% probability
• Jaylen Waddle: 34.5% probability
• Malik Washington: 23.5% probability

Bills vs. Dolphins latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Bills -9.5 (-105), Dolphins +9.5 (-110)
• Moneyline: Bills -470, Dolphins +410
• Total: Over/Under 49.5 (-120/-102)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Bills vs. Dolphins Week 10 details

The NFL Week 10 matchup between the Dolphins and Bills at Hard Rock Stadium is scheduled for November 9, 2025.

• Who: Buffalo Bills vs. Miami Dolphins
• Date: Sunday, November 9, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Hard Rock Stadium

NFL Week 10 betting promos and codes

Make the most of Dimers' Bills vs. Dolphins predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Bills, with a 78% win probability, will likely beat the Dolphins in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Dolphins matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.