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Buffalo Bills vs. Denver Broncos updated prediction featuring James Cook, RJ Harvey [Divisional Round, 2026]

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Written by Ryan Leaver

Get new expert Bills vs Broncos predictions for Saturday's game.

Buffalo Bills-Denver Broncos Latest Predictions and Betting Preview.
Predictions for the Buffalo Bills and Denver Broncos matchup at Empower Field at Mile High this Saturday.

Dimers' latest NFL predictions are live for Denver Broncos vs. Buffalo Bills in Divisional Round of the playoffs, with our model giving the Broncos a 56% of winning.

As Saturday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this AFC clash.

Since our early Broncos-Bills predictions, we’ve updated the win probabilities, score projections, and TD odds for James Cook, RJ Harvey, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—check out our Bills vs. Broncos page.

What's changed? Buffalo vs. Denver updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Bills vs. Broncos matchup stacks up. Here are the updated forecasts:

  • Straight Up Win Probabilities: Bills 44%, Broncos 56%
  • Predicted Final Score: Bills 21-23 Broncos
  • Spread: Bills (+1.5) 50%, Broncos (-1.5) 50%
  • Total Points (46.5): Over 48%, Under 52%

As of January 15, 2026, these Bills-Broncos figures reflect changes since our early-week simulation.

 

Anytime touchdown scorer predictions

New NFL player projections for the Divisional Round highlight the top candidates to find the end zone in Bills-Broncos on Saturday:

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Written by
Ryan Leaver
Senior Sports and Betting Editor

Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.

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