Buffalo Bills vs. Denver Broncos: Experts release early Divisional Round predictions [2026]

The Buffalo Bills and Denver Broncos will meet in the Divisional Round at Empower Field at Mile High on Saturday, January 17, 2026, starting at 4:30 PM ET.

Early simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this AFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Broncos predictions page.

Buffalo vs. Denver early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Broncos game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 44%, Broncos 56%
• Predicted final score: Bills 22-23 Broncos
• Spread: Bills (-1.5) 45%, Broncos (+1.5) 55%
• Total points (46.5): Over 50%, Under 50%

As of January 13, 2026, these Bills-Broncos calculations and predictions reflect the latest data and insights available.

Bills vs. Broncos Divisional Round details

Saturday's action between the Broncos and Bills at Empower Field at Mile High is scheduled for January 17, 2026.

• Who: Buffalo Bills vs. Denver Broncos
• Date: Saturday, January 17, 2026
• Time: 4:30 PM ET/1:30PM PT
• Venue: Empower Field at Mile High

Bills vs. Broncos opening odds

We've researched the best betting odds across America for this Divisional Round clash, which are listed here:

• Spread: Bills -1.5 (-102), Broncos +1.5 (-120)
• Moneyline: Bills -105, Broncos -108
• Total: Over/Under 46.5 (-110/-105)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for the Divisional Round highlight the top candidates to score a TD in Bills-Broncos in Week 20:

Buffalo Bills

• James Cook: 57.3% probability
• Josh Allen: 49.9% probability
• Khalil Shakir: 28.0% probability

Denver Broncos

• RJ Harvey: 53.4% probability
• Courtland Sutton: 34.8% probability
• Jaleel McLaughlin: 23.3% probability

Bills vs Broncos player props

James Cook is projected to lead rushing for the Bills, while RJ Harvey is expected to pace the Broncos on the ground.

In the receiving game, our projections favor Buffalo's Khalil Shakir and Denver's Courtland Sutton as the likely leaders for each team.

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Conclusion

We predict the Broncos, with a 56% win probability, will likely beat the Bills in this NFL postseason matchup. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Broncos game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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