Red Sox vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [6/5/2026]
Get Boston Red Sox vs New York Yankees predictions for MLB Friday.

The New York Yankees will take on the Boston Red Sox in MLB action at Yankee Stadium on Friday, beginning at 7:05 PM ET.
The Yankees will have Ryan Weathers (2-3, 3.52 ERA) as their starting pitcher, up against Sonny Gray (6-1, 3.06 ERA) for the Red Sox.
Based on the latest simulations, Dimers' proven MLB model predicts the Yankees as the most likely winner of the Red Sox vs. Yankees game.
This article offers a closer look at Friday's matchup, including best bets and picks.
Red Sox vs. Yankees prediction: Who will win and cover?
Our leading predictive model gives the Yankees a 57.7% chance of defeating the Red Sox.
According to our model, the Red Sox (+1.5) have a 60.0% chance of covering the run line, while the 8-run over/under has a 54.3% chance of going over.
Red Sox vs. Yankees odds [6/5/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Red Sox | Yankees |
|---|---|---|
| Run Line | +1.5 (-170) | -1.5 (+146) |
| Moneyline | +125 | -144 |
| Total | o8 (+100) | u8 (-122) |
All odds are correct at the time of publication and are subject to change.
Red Sox vs. Yankees picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +146 |
| Moneyline | Yankees | -144 |
| Total | Over 8 | +100 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Red Sox vs. Yankees game-day updates and essential details
Friday's MLB game between the Yankees and Red Sox at Yankee Stadium is scheduled to begin at 7:05 PM ET.
- Who: Boston Red Sox vs. New York Yankees
- Date: Friday, June 5, 2026
- Time: 7:05 PM ET/4:05PM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 57.7% win probability, will likely beat the Red Sox in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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