Falcons vs. Cardinals prediction: Why Atlanta is favored to win in NFL Week 16 [2025]

The Arizona Cardinals and Atlanta Falcons will lock horns in Week 16 of the NFL season at State Farm Stadium on Sunday, with kickoff at 4:05 PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the Falcons as the most likely winner of the Falcons vs. Cardinals game.

This article offers further insights into Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Falcons vs. Cardinals prediction: Who will win and cover?

Since our Falcons-Cardinals predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Falcons and Cardinals 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Falcons a 56% chance of defeating the Cardinals in Week 16 of the NFL season. Our predicted final score has the Falcons winning 24-23.

According to our model, the Cardinals (+2.5) have a 58% chance of covering the spread, while the 47.5-point over/under has a 53% chance of going over.

To see win probabilities for every matchup this week, check out our expert NFL Week 16 straight up picks.

Falcons vs. Cardinals odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Falcons	Cardinals
Spread	-2.5 (-115)	+2.5 (-102)
Moneyline	-148	+130
Total	o47.5 (-118)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

Falcons vs. Cardinals picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Cardinals +2.5	-102
Moneyline	Cardinals	+130
Total	Over 47.5	-118

According to our NFL best bets, the top play to make on this game is Cardinals +2.5 at the spread.

Falcons vs. Cardinals TD scorers

Who will score a touchdown in Falcons vs. Cardinals?

According to our list of touchdown scorer predictions for today, Bijan Robinson is most likely to score an anytime touchdown in Falcons vs. Cardinals.

Our projections give Robinson a 58.4% chance of scoring a TD at State Farm Stadium, while the running back is a 15.7% chance of registering the first touchdown the game.

Anytime touchdown scorer predictions

Atlanta Falcons

Player	Anytime TD Probability
Bijan Robinson (RB)	58.4%
Drake London (WR)	40.6%
Tyler Allgeier (RB)	38.3%
Kyle Pitts (TE)	32.7%
Darnell Mooney (WR)	18.9%

Arizona Cardinals

Player	Anytime TD Probability
Trey McBride (TE)	42.1%
Michael Carter (RB)	35.1%
Michael Wilson (WR)	34.5%
Marvin Harrison (WR)	29.6%
Emari Demercado (RB)	18.6%

First touchdown scorer predictions

Atlanta Falcons

Player	First TD Probability
Bijan Robinson (RB)	15.7%
Drake London (WR)	9.3%
Tyler Allgeier (RB)	8.6%
Kyle Pitts (TE)	7.1%
Darnell Mooney (WR)	3.8%

Arizona Cardinals

Player	First TD Probability
Trey McBride (TE)	9.6%
Michael Carter (RB)	7.6%
Michael Wilson (WR)	7.5%
Marvin Harrison (WR)	6.2%
Emari Demercado (RB)	3.6%

Falcons vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Falcons and Cardinals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 16 games.

Quarterbacks

Of the starting quarterbacks, the Falcons' Kirk Cousins is projected for 233 passing yards, while the Cardinals' Jacoby Brissett is expected to throw for 260 yards.

Player	Proj. Pass Yards
Kirk Cousins (ATL)	233
Jacoby Brissett (ARI)	260

Falcons rushing

Player	Proj. Rush Yards
Bijan Robinson	97
Tyler Allgeier	35
Kirk Cousins	2

Cardinals rushing

Player	Proj. Rush Yards
Michael Carter	52
Emari Demercado	22
Jacoby Brissett	15

Falcons receiving

Player	Proj. Rec. Yards
Drake London	72
Kyle Pitts	55
Bijan Robinson	39
Darnell Mooney	32
David Sills	21

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	71
Michael Wilson	62
Marvin Harrison	52
Michael Carter	23
Jalen Brooks	18

Falcons vs. Cardinals game-day updates and essential details

The NFL Week 16 action between the Cardinals and Falcons at State Farm Stadium is scheduled to start at 4:05 PM ET.

• Who: Atlanta Falcons vs. Arizona Cardinals
• Date: Sunday, December 21, 2025
• Time: 4:05 PM ET/1:05PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the Falcons, with a 56% win probability, will likely beat the Cardinals in Week 16 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Falcons vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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