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Arkansas State vs. SMU prediction: SMU favored to win men's college basketball matchup [11/21/2025]

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Written by Mac Douglass

Get Arkansas State vs SMU predictions for college basketball Friday.

Arkansas State-SMU Predictions and Game Preview.
Arkansas State vs. SMU men's college basketball prediction for Friday, November 21, 2025.

SMU and Arkansas State are scheduled to meet in men's college basketball action at Moody Coliseum on Friday, with tipoff at 9:00PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts SMU as the most likely winner of the Arkansas State vs. SMU game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Arkansas State vs. SMU prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball matchup between Arkansas State and SMU 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives SMU a 91% chance of defeating Arkansas State. Our predicted final score has SMU winning 89-73.

According to our model, SMU (-16.5) has a 51% chance of covering the spread, while the over/under total of 172.5 points has a 55% chance of staying under.

 

Arkansas State vs. SMU odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

Bet Type Arkansas State SMU
Spread +16.5 (-110) -16.5 (-105)
Moneyline +1200 -1600
Total o172.5 (-110) u172.5 (-105)

All odds are correct at the time of publication and are subject to change.

Arkansas State vs. SMU picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread SMU -16.5 -105
Moneyline Arkansas State +1200
Total Under 172.5 -105

According to our men's college basketball best bets, the top play to make on this game is Under 172.5 total points.

 

Arkansas State vs. SMU game-day updates and essential details

Friday's men's college basketball matchup between SMU and Arkansas State at Moody Coliseum is scheduled to start at 9:00PM ET.

  • Who: Arkansas State vs. SMU
  • Date: Friday, November 21, 2025
  • Time: 9:00PM ET/6:00PM PT
  • Venue: Moody Coliseum

Conclusion

We predict SMU, with a 91% win probability, will likely beat Arkansas State on Friday.

AI and automation have enhanced this article to quickly deliver accurate Arkansas State vs. SMU insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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