Cardinals vs. Bengals prediction: Why Cincinnati is favored to win in NFL Week 17 [2025]

The Cincinnati Bengals will face the Arizona Cardinals in NFL Week 17 action at Paycor Stadium on Sunday, starting at 1:00 PM ET.

Based on the latest simulations, Dimers' advanced NFL model projects the Bengals as the most likely winner of the Cardinals vs. Bengals game.

This article offers an expanded analysis of Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Cardinals vs. Bengals prediction: Who will win and cover?

Since our Cardinals-Bengals predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Cardinals and Bengals 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Bengals a 72% chance of defeating the Cardinals in Week 17 of the NFL season. Our predicted final score has the Bengals winning 30-23.

According to our model, the bookmakers have got it right, and the Cardinals and Bengals each have a 50% chance of covering the spread, while the 53.5-point over/under also has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 17 straight up picks.

Cardinals vs. Bengals odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Cardinals	Bengals
Spread	+7 (-110)	-7 (-110)
Moneyline	+290	-345
Total	o53.5 (-105)	u53.5 (-108)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Bengals picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Cardinals +7	-110
Moneyline	Cardinals	+290
Total	Over 53.5	-105

According to our best NFL bets, the top play to make on this game is Cardinals to win.

Cardinals vs. Bengals TD scorers

Who will score a touchdown in Cardinals vs. Bengals?

According to our list of touchdown scorer predictions for Week 17, Ja'Marr Chase is most likely to score an anytime touchdown in Cardinals vs. Bengals.

Our projections give Chase a 53.0% chance of scoring a TD at Paycor Stadium, while the wide receiver is an 11.6% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Arizona Cardinals

Player	Anytime TD Probability
Trey McBride (TE)	43.1%
Michael Carter (RB)	32.5%
Michael Wilson (WR)	32.1%
Marvin Harrison (WR)	27.2%
Emari Demercado (RB)	18.5%

Cincinnati Bengals

Player	Anytime TD Probability
Ja'Marr Chase (WR)	53.0%
Chase Brown (RB)	50.4%
Tee Higgins (WR)	47.2%
Samaje Perine (RB)	31.5%
Mike Gesicki (TE)	20.6%

First touchdown scorer predictions

Arizona Cardinals

Player	First TD Probability
Trey McBride (TE)	9.4%
Michael Carter (RB)	6.5%
Michael Wilson (WR)	6.4%
Marvin Harrison (WR)	5.3%
Emari Demercado (RB)	3.4%

Cincinnati Bengals

Player	First TD Probability
Ja'Marr Chase (WR)	11.6%
Chase Brown (RB)	10.8%
Tee Higgins (WR)	9.8%
Samaje Perine (RB)	5.8%
Mike Gesicki (TE)	3.5%

Cardinals vs Bengals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Bengals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 17 games.

Quarterbacks

Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected to have a big game with 265 passing yards. The Bengals' Joe Burrow is expected to throw for a whopping 275 yards.

Player	Proj. Pass Yards
Jacoby Brissett (ARI)	265
Joe Burrow (CIN)	275

Cardinals rushing

Player	Proj. Rush Yards
Michael Carter	50
Emari Demercado	21
Corey Kiner	19

Bengals rushing

Player	Proj. Rush Yards
Chase Brown	61
Samaje Perine	39
Joe Burrow	8

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	81
Michael Wilson	55
Marvin Harrison	43
Elijah Higgins	24
Michael Carter	20

Bengals receiving

Player	Proj. Rec. Yards
Ja'Marr Chase	93
Tee Higgins	63
Mike Gesicki	30
Chase Brown	26
Andrei Iosivas	20

Cardinals vs. Bengals game-day updates and essential details

The NFL Week 17 matchup between the Bengals and Cardinals at Paycor Stadium is scheduled to start at 1:00 PM ET.

• Who: Arizona Cardinals vs. Cincinnati Bengals
• Date: Sunday, December 28, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Paycor Stadium

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Conclusion

We predict the Bengals, with a 72% win probability, will likely beat the Cardinals in Week 17 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Bengals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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