San Francisco 49ers vs. Seattle Seahawks Predictions

Full NFL betting guide for San Francisco 49ers vs. Seattle Seahawks at Lumen Field on Sunday December 5, 2021, 4:25PM ET. Get game predictions, best bets, best promos and live updates here.

49ers vs. Seahawks Game - Dec 5, 2021, 4:25PM ET

Get free picks and player props for 49ers vs. Seahawks at Lumen Field on Sunday 5 December, 2021, 4:25PM ET, here at

Based on trusted data and analytics, our computer has simulated 49ers-Seahawks 10,000 times to predict the most likely outcomes.

Like betting on the NFL? Use this page for everything you need to know about 49ers vs. Seahawks in 2021 and bet now with the legal sportsbooks in your state.

49ers-Seahawks 2021 Score

Dimers has live updates and live predictions for 49ers vs. Seahawks on Dec 5, 2021, 4:25PM ET.

Follow all the 49ers-Seahawks action from Lumen Field here, including live scores, play-by-play commentary, and live win probabilities.

Who will win 49ers vs. Seahawks today? has predicted the final score and features Spread, Over/Under and Moneyline probabilities for 49ers vs. Seahawks on Sunday 5 December, 2021.

Our 49ers-Seahawks best bets are posted following 1000s of simulations, while our best NFL promos are tailored to your location.

See our NFL Predictions page for more free NFL picks and score predictions.

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