49ers vs. Seahawks prediction favors Seattle to win in NFL Week 5 [2026]

Since our 49ers-Seahawks predictions earlier in the week, we have re-simulated the result of Sunday's NFL matchup between the 49ers and Seahawks, forming part of our NFL predictions coverage.

Our leading predictive model gives the Seahawks a 58.0% chance of defeating the 49ers in Week 5 of the NFL season. Our predicted final score has the Seahawks winning 24-22.

Key factors favoring the Seahawks:

• Seahawks team rating
• Seahawks offense
• Seahawks defense

According to our model, the 49ers (+3.5) have a 60.8% chance of covering the spread, while the 46.5-point over/under has a 53.5% chance of going over.

The main contributing factors to the over being more likely are:

• Seahawks recent performance
• 49ers recent performance

To see win probabilities for every matchup this week, check out our expert NFL Week 5 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: 49ers +3.5 (-115) / Seahawks -3.5 (+113)
• Moneyline: 49ers +156, Seahawks -160
• Total: Over/Under 46.5 (-102/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: 49ers +3.5 @ 53¢ via Novig
• Moneyline: 49ers @ 39¢ via Polymarket
• Total: Over 46.5 @ 50¢ via Novig

According to our NFL best bets, the top play to make on this game is 49ers +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

49ers vs. Seahawks TD scorers

Who will score a touchdown in 49ers vs. Seahawks?

According to our list of touchdown scorer predictions for Week 5, Jaxon Smith-Njigba is most likely to score an anytime touchdown in 49ers vs. Seahawks.

Our projections give Smith-Njigba a 54.7% chance of scoring a TD at Lumen Field, while the wide receiver is a 13.9% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

San Francisco 49ers

• Christian McCaffrey (RB): 52.0% probability
• Mike Evans (WR): 32.3%
• George Kittle (TE): 32.0%
• Deebo Samuel (WR): 23.8%
• Brock Purdy (QB): 14.0%

Seattle Seahawks

• Jaxon Smith-Njigba (WR): 54.7% prob.
• Emanuel Wilson (RB): 47.6%
• AJ Barner (TE): 24.2%
• George Holani (RB): 21.9%
• Rashid Shaheed (WR): 18.9%

First touchdown scorer predictions

San Francisco 49ers

• Christian McCaffrey (RB): 13.7% prob.
• Mike Evans (WR): 7.3%
• George Kittle (TE): 7.2%
• Deebo Samuel (WR): 5.1%
• Brock Purdy (QB): 2.8%

Seattle Seahawks

• Jaxon Smith-Njigba (WR): 13.9% prob.
• Emanuel Wilson (RB): 11.3%
• AJ Barner (TE): 4.9%
• George Holani (RB): 4.3%
• Rashid Shaheed (WR): 3.7%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Seahawks. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 5 games.

Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 231 passing yards, while the Seahawks' Sam Darnold is expected to throw for 231 yards.

49ers rushing

• Christian McCaffrey: 57 yds
• Brock Purdy: 24 yds
• Kaelon Black: 18 yds

Seahawks rushing

• Emanuel Wilson: 67 yds
• George Holani: 24 yds
• Sam Darnold: 9 yds

49ers receiving

• Mike Evans: 55 yds
• George Kittle: 53 yds
• Deebo Samuel: 40 yds
• Christian McCaffrey: 38 yds
• Jacob Cowing: 18 yds

Seahawks receiving

• Jaxon Smith-Njigba: 97 yds
• Cooper Kupp: 30 yds
• Rashid Shaheed: 28 yds
• AJ Barner: 27 yds
• Tory Horton: 18 yds

Game info & kickoff details

The NFL Week 5 game between the Seahawks and 49ers at Lumen Field is scheduled to commence at 4:25 PM ET.

• Who: San Francisco 49ers vs. Seattle Seahawks
• Date: Sunday, October 11, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: Lumen Field

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Conclusion

We predict the Seahawks, with a 58.0% win probability, will likely beat the 49ers in Week 5 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.