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Women's March Madness picks today: Wednesday's First Four best bets include Samford vs. Southern University play [3/18/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get women's March Madness picks and NCAA Tournament best bets for Wednesday, March 18, 2026.
Today’s women's March Madness picks for March 18, 2026 are here, with Samford vs. Southern University and Arizona State vs. Virginia among the First Four matchups identified as top value plays across Wednesday’s women's NCAA Tournament action.
Dimers’ predictive analytics engine runs 24/7, searching the latest women's basketball odds to discover top betting edges throughout the bracket. The result? Data-backed plays that help Dimers Pro members make smarter decisions.
List of women's March Madness picks tonight [3/18, updated 10:40PM ET]
Below, you’ll find today’s top women's March Madness bets, ranked by edge for Wednesday, March 18, 2026.
Samford ML (+136)
- Edge: 5.2%
- Probability: 47.6%
- Matchup: Samford vs. Southern University (7:00PM ET, Thursday)
Our model has identified value on Samford to defeat Southern University at +136 odds. A 47.6% probability produces an edge of 5.2%, making this the strongest play for today's First Four slate.
Virginia ML (-144)
- Edge: 4.6%
- Probability: 63.6%
- Matchup: Arizona State vs. Virginia (9:00PM ET, Thursday)
Virginia ML carries a 4.6% edge and a probability of 63.6% at -144 odds, according to our model.
Samford +3.5 (-110)
- Edge: 2.1%
- Probability: 54.5%
- Matchup: Samford vs. Southern University (7:00PM ET, Thursday)
Samford +3.5 vs. Southern University at -110 odds shows a 2.1% edge, supported by a 54.5% probability in simulations.
Women's March Madness best bets summary: Wednesday, 3/18/2026
As of 10:40PM ET, here are our top women's March Madness bets by edge:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Samford vs. Southern University | Samford ML | +136 @ DraftKings | 5.2% | 47.6% |
| Arizona State vs. Virginia | Virginia ML | -144 @ FanDuel | 4.6% | 63.6% |
| Samford vs. Southern University | Samford +3.5 | -110 @ FanDuel | 2.1% | 54.5% |
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Conclusion
Today's women's March Madness best bets are locked and loaded for March 18, 2026, featuring plays such as Samford ML and Virginia ML. Powered by advanced simulations, these picks are here to boost your betting game.
All odds and probabilities in this article are correct and accurate at the time of publication.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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