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Virginia vs. Louisville prediction: Louisville favored to win women's basketball matchup [2/22/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Virginia vs Louisville predictions for college basketball Sunday.
Louisville will take on Virginia in women's college basketball action at KFC Yum! Center on Sunday, commencing at 12:00 PM ET.
Based on the latest simulation results, Dimers' new women's basketball model projects Louisville as the most likely winner of the Virginia vs. Louisville game.
This article offers further insights into Sunday's matchup, including best bets and picks.
Virginia vs. Louisville prediction: Who will win?
Using trusted machine learning and data, we have simulated the result of Sunday's women's basketball game between Virginia and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our independent predictive model currently gives Louisville a 94% chance of defeating Virginia.
According to our model, the over/under total of 139.5 points also has an equal 50-50 chance of hitting.
Virginia vs. Louisville odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Virginia | Louisville |
|---|---|---|
| Spread | +15.5 (-110) | -15.5 (-110) |
| Moneyline | +950 | -1639 |
| Total | o139.5 (-110) | u139.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Virginia vs. Louisville picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville -15.5 | -110 |
| Moneyline | Louisville | -1639 |
| Total | Under 139.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Louisville to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Virginia vs. Louisville game-day updates and essential details
Sunday's women's basketball game between Louisville and Virginia at KFC Yum! Center is scheduled to begin at 12:00 PM ET.
- Who: Virginia vs. Louisville
- Date: Sunday, February 22, 2026
- Time: 12:00 PM ET/9:00AM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with a 94% win probability, will likely beat Virginia on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Virginia vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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