Villanova vs. DePaul prediction: Villanova favored to win men's college basketball matchup [3/4/2026]

DePaul will face Villanova in men's college basketball action at Wintrust Arena on Wednesday, starting at 8:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model projects Villanova as the most likely winner of the Villanova vs. DePaul game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Villanova vs. DePaul prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Villanova and DePaul 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Villanova a 57% chance of defeating DePaul. Our predicted final score has Villanova winning 69-68.

According to our model, DePaul (+2.5) has a 51% chance of covering the spread, while the over/under total of 135.5 points has a 54% chance of going over.

Villanova vs. DePaul odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type	Villanova	DePaul
Spread	-2.5 (-102)	+2.5 (-118)
Moneyline	-140	+120
Total	o135.5 (-108)	u135.5 (-105)

All odds are correct at the time of publication and are subject to change.

Villanova vs. DePaul picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Villanova -2.5	-102
Moneyline	Villanova	-140
Total	Over 135.5	-108

According to our men's college basketball best bets, the top play to make on this game is Over 135.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Villanova vs. DePaul game-day updates and essential details

Wednesday's men's college basketball action between DePaul and Villanova at Wintrust Arena is scheduled to start at 8:00 PM ET.

• Who: Villanova vs. DePaul
• Date: Wednesday, March 4, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Wintrust Arena

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Conclusion

We predict Villanova, with a 57% win probability, will likely beat DePaul on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Villanova vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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