USC vs. Washington prediction: Why Washington is favored to win men's college basketball matchup [3/4/2026]

Washington and USC are scheduled to meet in men's college basketball action at Alaska Airlines Arena at Hec Edmundson Pavilion on Wednesday, starting at 10:30 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Washington as the most likely winner of the USC vs. Washington game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

USC vs. Washington prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between USC and Washington 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Washington a 67% chance of defeating USC. Our predicted final score has Washington winning 79-75.

According to our model, USC (+5.5) has a 53% chance of covering the spread, while the 151.5-point over/under has a 54% chance of going over.

USC vs. Washington odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type	USC	Washington
Spread	+5.5 (-115)	-5.5 (-102)
Moneyline	+202	-210
Total	o151.5 (-105)	u151.5 (-115)

All odds are correct at the time of publication and are subject to change.

USC vs. Washington picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	USC +5.5	-115
Moneyline	USC	+202
Total	Over 151.5	-105

According to our men's college basketball best bets, the top play to make on this game is Over 151.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

USC vs. Washington game-day updates and essential details

Wednesday's men's college basketball action between Washington and USC at Alaska Airlines Arena at Hec Edmundson Pavilion is scheduled to commence at 10:30 PM ET.

• Who: USC vs. Washington
• Date: Wednesday, March 4, 2026
• Time: 10:30 PM ET/7:30PM PT
• Venue: Alaska Airlines Arena at Hec Edmundson Pavilion

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Conclusion

We predict Washington, with a 67% win probability, will likely beat USC on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate USC vs. Washington insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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