USC vs. South Carolina prediction: South Carolina favored to win women's March Madness Second Round matchup [3/23/2026]

South Carolina and USC will lock horns in women's March Madness Second Round action at Colonial Life Arena on Monday, with tipoff at 8:00 PM ET.

Based on updated simulations, Dimers' new women's basketball model projects South Carolina as the most likely winner of the USC vs. South Carolina game.

This article offers an expanded analysis of Monday's matchup, including best bets and picks.

USC vs. South Carolina prediction: Who will win and advance to the Sweet Sixteen?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's NCAAW Tournament matchup between USC and South Carolina 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model currently gives South Carolina a 98% chance of defeating USC.

According to our model, the 133.5-point over/under has a 51% chance of going over.

USC vs. South Carolina odds

We have sourced the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

USC vs. South Carolina picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our women's college basketball best bets, the top play to make on this game is USC to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

USC vs. South Carolina game-day updates and essential details

Monday's women's basketball game between South Carolina and USC at Colonial Life Arena is scheduled to begin at 8:00 PM ET.

• Who: USC vs. South Carolina
• Date: Monday, March 23, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Colonial Life Arena
• March Madness stage: Second Round

College basketball betting and fantasy promos and codes

Make the most of Dimers' USC vs. South Carolina predictions by exploring the below offers from OG, Bet365, BetMGM, and Thrillzz.

Conclusion

We predict South Carolina, with a 98% win probability, will likely beat USC this women's March Madness Second Round matchup.

AI and automation have enhanced this article to quickly deliver accurate USC vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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