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USC vs. South Carolina prediction: South Carolina favored to win women's March Madness Second Round matchup [3/23/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get USC vs South Carolina predictions for college basketball Monday.
South Carolina will square off with USC in March Madness Second Round action at Colonial Life Arena on Monday, commencing at 8:00 PM ET.
Based on updated simulation results, Dimers' new women's basketball model predicts South Carolina as the most likely winner of the USC vs. South Carolina game.
This article offers further insights into Monday's matchup, including best bets and picks.
USC vs. South Carolina prediction: Who will win and advance to the Sweet Sixteen?
Using trusted machine learning and data, we have simulated the result of Monday's NCAAW Tournament matchup between USC and South Carolina 10,000 times as part of our women's college basketball predictions coverage.
Our famous predictive model currently gives South Carolina a 98% chance of beating USC.
According to our model, the over/under total of 133.5 points has a 51% chance of going over.
USC vs. South Carolina odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | USC | South Carolina |
|---|---|---|
| Spread | +24.5 (-112) | -24.5 (-108) |
| Moneyline | +3000 | -10000 |
| Total | o133.5 (-110) | u133.5 (-110) |
All odds are correct at the time of publication and are subject to change.
USC vs. South Carolina picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina -24.5 | -108 |
| Moneyline | South Carolina | -10000 |
| Total | Over 133.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is South Carolina -24.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
USC vs. South Carolina game-day updates and essential details
Monday's women's basketball action between South Carolina and USC at Colonial Life Arena is scheduled to begin at 8:00 PM ET.
- Who: USC vs. South Carolina
- Date: Monday, March 23, 2026
- Time: 8:00 PM ET/5:00PM PT
- Venue: Colonial Life Arena
- March Madness stage: Second Round
College basketball betting and fantasy promos and codes
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Conclusion
We predict South Carolina, with a 98% win probability, will likely beat USC this women's March Madness Second Round matchup.
AI and automation have enhanced this article to quickly deliver accurate USC vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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