Blue Jays vs. Diamondbacks prediction: Why Arizona is favored to win Friday's MLB matchup [4/17/2026]

MLB action continues on Friday at 9:40 PM ET as the Toronto Blue Jays square off with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will start Michael Soroka (3-0, 2.87 ERA), while the Blue Jays have opted for Eric Lauer (1-2, 7.82 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Diamondbacks as the most likely winner of the Blue Jays vs. Diamondbacks game.

This article offers a closer look at Friday's matchup, including best bets and picks.

Blue Jays vs. Diamondbacks prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Blue Jays and Diamondbacks, forming part of our MLB predictions coverage.

Our famous predictive model currently gives the Diamondbacks a 57% chance of defeating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 59% chance of covering the run line, while the 9-run over/under has a 54% chance of going over.

Blue Jays vs. Diamondbacks odds [4/17/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Blue Jays vs. Diamondbacks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: