Toledo vs. Louisville prediction: Louisville favored to win in college football Week 18 [2025]

Louisville will take on Toledo in Week 18 college football action at Flagler Credit Union Stadium on Tuesday, with kickoff at 2:00 PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Louisville as the most likely winner of the Toledo vs. Louisville game.

This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Toledo vs. Louisville prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Toledo vs. Louisville 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Louisville a 73% chance of beating Toledo. Our predicted final score has Louisville winning 26-18.

According to our model, Toledo (+8.5) has a 52% chance of covering the spread, while the over/under total of 43.5 points has a 56% chance of staying under.

Toledo vs. Louisville odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Toledo vs. Louisville picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: