Tennessee vs. Iowa State prediction: Why Iowa State is favored to win men's March Madness Sweet Sixteen matchup [3/27/2026]

Iowa State and Tennessee are scheduled to meet in March Madness Sweet Sixteen action at United Center on Friday, starting at 10:25 PM ET.

For this March Madness Sweet Sixteen game, Iowa State—led by the best trio in college basketball— come up against Tennessee, an elite rebounding team built around defense.

Based on updated simulations, Dimers' advanced college basketball model predicts Iowa State as the most likely winner of the Tennessee vs. Iowa State game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Tennessee vs. Iowa State prediction: Who will win and advance to the Elite Eight?

Using powerful machine learning and data, we have simulated the result of Friday's NCAAM Tournament game between Tennessee and Iowa State, forming part of our men's college basketball predictions coverage.

Our leading predictive model gives Iowa State a 66% chance of defeating Tennessee. Our predicted final score has Iowa State winning 72-68.

According to our model, Iowa State (-2.5) has a 62% chance of covering the spread, while the over/under total of 140.5 points has a 53% chance of going over.

Tennessee vs. Iowa State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type	Tennessee	Iowa State
Spread	+2.5 (-105)	-2.5 (-110)
Moneyline	+140	-162
Total	o140.5 (-105)	u140.5 (-115)

All odds are correct at the time of publication and are subject to change.

Tennessee vs. Iowa State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Iowa State -2.5	-110
Moneyline	Iowa State	-162
Total	Over 140.5	-105

According to our men's college basketball best bets, the top play to make on this game is Iowa State -2.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Tennessee vs. Iowa State game-day updates and essential details

Friday's men's college basketball game between Iowa State and Tennessee at United Center is scheduled to begin at 10:25 PM ET.

• Who: Tennessee vs. Iowa State
• Date: Friday, March 27, 2026
• Time: 10:25 PM ET/7:25PM PT
• Venue: United Center
• March Madness stage: Sweet 16

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Conclusion

We predict Iowa State, with a 66% win probability, will likely beat Tennessee this men's March Madness Sweet Sixteen matchup.

AI and automation have enhanced this article to quickly deliver accurate Tennessee vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.

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