Titans vs. Colts prediction: Why Indianapolis is favored to win in NFL Week 8, 2025

NFL Week 8 action continues on Sunday at 4:25PM ET as the Tennessee Titans square off with the Indianapolis Colts at Lucas Oil Stadium.

Based on updated simulations, Dimers' advanced NFL model projects the Colts as the most likely winner of the Titans vs. Colts game.

This article offers an expanded analysis of this week's matchup, including touchdown scorer projections, best bets and player prop picks.

Titans vs. Colts prediction: Who will win, cover the spread?

Since our Titans-Colts predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Titans and Colts 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Colts a 90% chance of beating the Titans in Week 8 of the NFL season. Our predicted final score has the Colts winning 30-16.

According to our model, the Titans (+15.5) have a 53% chance of covering the spread, while the over/under total of 47.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 8 straight up picks.

Titans vs. Colts odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Titans	Colts
Spread	+15.5 (-115)	-15.5 (-105)
Moneyline	+950	-1500
Total	o47.5 (-114)	u47.5 (-102)

All odds are correct at the time of publication and are subject to change.

Titans vs. Colts picks and best bet

Our probabilities, matched with the listed odds, reveal the top betting picks for this game, detailed in Dimers' NFL best bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Titans +15.5	-115
Moneyline	Titans	+950
Total	Under 47.5	-102

According to our NFL best bets, the top play to make on this game is Titans moneyline.

Titans vs. Colts TD scorers

Who will score a touchdown in Titans vs. Colts?

According to our list of touchdown scorer predictions for Week 8, Jonathan Taylor is most likely to score an anytime TD in Titans vs. Colts.

Our projections give Taylor a 69.0% chance of scoring a TD at Lucas Oil Stadium, while the running back is a 20.4% chance of registering the first touchdown the game.

Anytime touchdown scorer predictions

Tennessee Titans

Player	Anytime TD Probability
Tony Pollard (RB)	28.7%
Elic Ayomanor (WR)	23.9%
Tyjae Spears (RB)	23.1%
Chimere Dike (WR)	18.0%
Gunnar Helm (TE)	15.1%

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor (RB)	69.0%
Tyler Warren (TE)	38.9%
Daniel Jones (QB)	30.5%
Michael Pittman (WR)	30.4%
Josh Downs (WR)	21.3%

First touchdown scorer predictions

Tennessee Titans

Player	First TD Probability
Tony Pollard (RB)	6.9%
Elic Ayomanor (WR)	5.5%
Tyjae Spears (RB)	5.4%
Chimere Dike (WR)	4.1%
Gunnar Helm (TE)	3.3%

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor (RB)	20.4%
Tyler Warren (TE)	8.6%
Daniel Jones (QB)	6.3%
Michael Pittman (WR)	6.3%
Josh Downs (WR)	4.2%

Titans vs Colts player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Titans and Colts. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 8 games.

Quarterbacks

Of the starting quarterbacks, the Titans' Cam Ward is projected for 214 passing yards, while the Colts' Daniel Jones is expected to throw for 240 yards.

Player	Proj. Pass Yards
Cam Ward (TEN)	214
Daniel Jones (IND)	240

Titans rushing

Player	Proj. Rush Yards
Tony Pollard	45
Tyjae Spears	24
Cam Ward	10

Colts rushing

Player	Proj. Rush Yards
Jonathan Taylor	95
Daniel Jones	17
Ameer Abdullah	14

Titans receiving

Player	Proj. Rec. Yards
Elic Ayomanor	43
Van Jefferson	36
Chimere Dike	35
Chig Okonkwo	31
Gunnar Helm	26

Colts receiving

Player	Proj. Rec. Yards
Tyler Warren	58
Michael Pittman	56
Alec Pierce	44
Josh Downs	42
Jonathan Taylor	22

Titans vs. Colts game-day updates and essential details

The NFL Week 8 action between the Colts and Titans at Lucas Oil Stadium is scheduled to start at 4:25PM ET.

• Who: Tennessee Titans vs. Indianapolis Colts
• Date: Sunday, October 26, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Lucas Oil Stadium

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Conclusion

We predict the Colts, with a 90% win probability, will likely beat the Titans in Week 8 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Titans vs. Colts insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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