Tennessee State vs. Iowa State prediction: Why Iowa State is favored to win men's March Madness First Round matchup [3/20/2026]

Men's college basketball action continues on Friday at 2:50 PM ET as Tennessee State faces off with the favored Iowa State in First Round action at Enterprise Center.

Based on the latest simulations, Dimers' proven college basketball model predicts Iowa State as the most likely winner of the Tennessee State vs. Iowa State game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Tennessee State vs. Iowa State prediction: Who will win and advance to the Second Round?

Using trusted machine learning and data analysis, we have simulated the outcome of Friday's NCAAM Tournament game between Tennessee State and Iowa State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Iowa State a 98% chance of beating Tennessee State. Our predicted final score has Iowa State winning 86-61.

According to our model, Iowa State (-24.5) has a 51% chance of covering the spread, while the over/under total of 147.5 points has a 52% chance of going over.

Tennessee State vs. Iowa State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type	Tennessee State	Iowa State
Spread	+24.5 (-102)	-24.5 (-115)
Moneyline	+3000	-8000
Total	o147.5 (-105)	u147.5 (-108)

All odds are correct at the time of publication and are subject to change.

Tennessee State vs. Iowa State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Tennessee State +24.5	-102
Moneyline	Iowa State	-8000
Total	Over 147.5	-105

According to our men's college basketball best bets, the top play to make on this game is Over 147.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Tennessee State vs. Iowa State game-day updates and essential details

Friday's men's college basketball matchup between Iowa State and Tennessee State at Enterprise Center is scheduled to begin at 2:50 PM ET.

• Who: Tennessee State vs. Iowa State
• Date: Friday, March 20, 2026
• Time: 2:50 PM ET/11:50AM PT
• Venue: Enterprise Center
• March Madness stage: First Round

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Conclusion

We predict Iowa State, with a 98% win probability, will likely beat Tennessee State this men's March Madness First Round matchup.

AI and automation have enhanced this article to quickly deliver accurate Tennessee State vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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