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Syracuse vs. Wake Forest prediction: Why Wake Forest is favored to win men's college basketball matchup [2/28/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Syracuse vs Wake Forest predictions for college basketball Saturday.
Wake Forest will face Syracuse in men's college basketball action at Lawrence Joel Veterans Memorial Coliseum on Saturday, commencing at 5:45 PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts Wake Forest as the most likely winner of the Syracuse vs. Wake Forest game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Syracuse vs. Wake Forest prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Syracuse and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives Wake Forest a 60% chance of beating Syracuse. Our predicted final score has Wake Forest winning 76-74.
According to our model, Syracuse (+3.5) has a 56% chance of covering the spread, while the 152.5-point over/under has a 53% chance of staying under.
Syracuse vs. Wake Forest odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Syracuse | Wake Forest |
|---|---|---|
| Spread | +3.5 (-110) | -3.5 (-110) |
| Moneyline | +150 | -175 |
| Total | o152.5 (-105) | u152.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Syracuse vs. Wake Forest picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Syracuse +3.5 | -110 |
| Moneyline | Syracuse | +150 |
| Total | Under 152.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Syracuse +3.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Syracuse vs. Wake Forest game-day updates and essential details
Saturday's men's college basketball action between Wake Forest and Syracuse at Lawrence Joel Veterans Memorial Coliseum is scheduled to start at 5:45 PM ET.
- Who: Syracuse vs. Wake Forest
- Date: Saturday, February 28, 2026
- Time: 5:45 PM ET/2:45PM PT
- Venue: Lawrence Joel Veterans Memorial Coliseum
Conclusion
We predict Wake Forest, with a 60% win probability, will likely beat Syracuse on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Wake Forest insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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