Syracuse vs. Iowa State prediction: Why Iowa State is favored to win women's March Madness First Round matchup [3/21/2026]

Iowa State and Syracuse will meet in women's March Madness First Round action at Harry A. Gampel Pavilion on Saturday, starting at 5:30 PM ET.

Based on updated simulation results, Dimers' new women's basketball model projects Iowa State as the most likely winner of the Syracuse vs. Iowa State game.

This article offers a closer look at Saturday's matchup, including best bets and picks.

Syracuse vs. Iowa State prediction: Who will win and advance to the Second Round?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's NCAAW Tournament matchup between Syracuse and Iowa State 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model currently gives Iowa State a 64% chance of beating Syracuse.

According to our model, the 149.5-point over/under has a 55% chance of going over.

Syracuse vs. Iowa State odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Syracuse vs. Iowa State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our women's college basketball best bets, the top play to make on this game is Syracuse to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Syracuse vs. Iowa State game-day updates and essential details

Saturday's women's basketball game between Iowa State and Syracuse at Harry A. Gampel Pavilion is scheduled to start at 5:30 PM ET.

• Who: Syracuse vs. Iowa State
• Date: Saturday, March 21, 2026
• Time: 5:30 PM ET/2:30PM PT
• Venue: Harry A. Gampel Pavilion
• March Madness stage: First Round

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Conclusion

We predict Iowa State, with a 64% win probability, will likely beat Syracuse this women's March Madness First Round matchup.

AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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