Cardinals vs. Marlins prediction: Why Miami is favored to win Tuesday's MLB matchup [4/21/2026]

MLB action continues on Tuesday at 6:40 PM ET as the St. Louis Cardinals lock horns with the Miami Marlins at loanDepot park.

The Marlins will start Chris Paddack (0-3, 5.59 ERA), up against Dustin May (2-2, 6.98 ERA) for the Cardinals.

Based on the latest simulation results, Dimers' proven MLB model gives the Marlins a slight edge with a 53% win probability over the Cardinals.

This article offers an expanded analysis of Tuesday's Cardinals vs. Marlins matchup, including best bets and picks.

Cardinals vs. Marlins prediction: Who will win?

Using powerful machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Cardinals and Marlins, forming part of our MLB predictions coverage.

Our independent predictive model gives the Marlins a 53% chance of beating the Cardinals.

According to our model, the over/under total of 8.5 runs also has an equal 50-50 chance of hitting.

Cardinals vs. Marlins odds [4/21/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Marlins picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: