Blues vs. Sabres prediction: Buffalo favored to win Thursday's NHL matchup [11/6/2025]

NHL action continues on Thursday at 7:00PM ET as the St. Louis Blues square off with the Buffalo Sabres at KeyBank Center.

Based on the latest simulations, Dimers' advanced NHL model predicts the Sabres as the most likely winner of the Blues vs. Sabres game.

This article offers an expanded analysis of Thursday's matchup, including goal scorer projections, best bets and player prop picks.

Blues vs. Sabres prediction: Who will win, cover the puck line?

Using trusted machine learning and data, we have simulated the result of Thursday's NHL game between the Blues and Sabres 10,000 times as part of our NHL predictions coverage.

Our independent predictive model gives the Sabres a 53% chance of beating the Blues.

According to our model, the Blues (+1.5) have a 68% chance of covering the puck line, while the 6.5-goal over/under has a 52% chance of staying under.

Blues vs. Sabres odds

We have researched the best NHL odds in America for this game, which are listed here:

Bet Type	Blues	Sabres
Puck Line	+1.5 (-210)	-1.5 (+190)
Moneyline	+114	-130
Total	o6.5 (+100)	u6.5 (-120)

All odds are correct at the time of publication and are subject to change.

Blues vs. Sabres picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Puck Line	Blues +1.5	-210
Moneyline	Blues	+114
Total	Over 6.5	+100

According to our best NHL bets, the top play to make on this game is Blues to win.

Blues vs. Sabres player props

Who will score a goal in Blues vs. Sabres?

According to our model, Tage Thompson is most likely to score an anytime goal in Blues vs. Sabres.

Our projections give Thompson a 43.2% chance of scoring a goal at KeyBank Center, while the star is an 8.3% chance of netting the first goal the game.

Anytime goal scorer predictions

St. Louis Blues

Player	Anytime Goal Probability
Jordan Kyrou	32.6%
Dylan Holloway	31.2%
Robert Thomas	24.4%
Pius Suter	23.8%
Jimmy Snuggerud	23.4%

Buffalo Sabres

Player	Anytime Goal Probability
Tage Thompson	43.2%
Alex Tuch	34.6%
Ryan McLeod	24.4%
Jack Quinn	23.6%
Rasmus Dahlin	19.7%

First goal scorer predictions

St. Louis Blues

Player	First Goal Probability
Jordan Kyrou	6.3%
Dylan Holloway	5.5%
Pius Suter	4.6%
Robert Thomas	4.3%
Jimmy Snuggerud	4.0%

Buffalo Sabres

Player	First Goal Probability
Tage Thompson	8.3%
Alex Tuch	6.7%
Jack Quinn	4.4%
Ryan McLeod	4.3%
Josh Doan	3.7%

Blues vs. Sabres game-day updates and essential details

Thursday's matchup between the Sabres and Blues at KeyBank Center is scheduled to begin at 7:00PM ET.

• Who: St. Louis Blues vs. Buffalo Sabres
• Date: Thursday, November 6, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: KeyBank Center

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Conclusion

We predict the Sabres, with a 53% win probability, will likely beat the Blues on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Blues vs. Sabres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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