St. John's vs. Kansas prediction: St. John's favored to win men's March Madness Second Round matchup [3/22/2026]

Kansas and St. John's will lock horns in March Madness Second Round action at Viejas Arena on Sunday, starting at 5:15 PM ET.

For this Second Round matchup, Kansas—a mysterious roster dependent on freshman star Darryn Peterson— come up against St. John's, an athletic, long roster still searching for a steady point guard.

Based on the latest simulation results, Dimers' advanced college basketball model predicts St. John's as the most likely winner of the St. John's vs. Kansas game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

St. John's vs. Kansas prediction: Who will win and advance to the Sweet Sixteen?

Using innovative machine learning and data, we have simulated the outcome of Sunday's NCAAM Tournament game between St. John's and Kansas 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives St. John's a 58% chance of defeating Kansas. Our predicted final score has St. John's winning 75-73.

According to our model, Kansas (+3.5) has a 58% chance of covering the spread, while the 144.5-point over/under has a 56% chance of going over.

St. John's vs. Kansas odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

St. John's vs. Kansas picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Kansas +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

St. John's vs. Kansas game-day updates and essential details

Sunday's men's college basketball game between Kansas and St. John's at Viejas Arena is scheduled to commence at 5:15 PM ET.

• Who: St. John's vs. Kansas
• Date: Sunday, March 22, 2026
• Time: 5:15 PM ET/2:15PM PT
• Venue: Viejas Arena
• March Madness stage: Second Round

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Conclusion

We predict St. John's, with a 58% win probability, will likely beat Kansas this men's March Madness Second Round matchup.

AI and automation have enhanced this article to quickly deliver accurate St. John's vs. Kansas insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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