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St. John's vs. DePaul prediction: St. John's favored to win women's college basketball matchup [2/10/2026]
Get St. John's vs DePaul predictions for college basketball Tuesday.

DePaul will face the favored St. John's in women's college basketball action at Wintrust Arena on Tuesday, starting at 7:00 PM ET.
Based on updated simulations, Dimers' new women's basketball model projects St. John's as the most likely winner of the St. John's vs. DePaul game.
This article offers a closer look at Tuesday's matchup, including best bets and picks.
St. John's vs. DePaul prediction: Who will win?
Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's women's basketball matchup between St. John's and DePaul 10,000 times as part of our women's college basketball predictions coverage.
Our famous predictive model gives St. John's a 77% chance of defeating DePaul.
According to our model, the over/under total of 127.5 points has a 51% chance of going over.
St. John's vs. DePaul odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | St. John's | DePaul |
|---|---|---|
| Spread | -7.5 (-106) | +7.5 (-125) |
| Moneyline | -380 | +250 |
| Total | o127.5 (-114) | u127.5 (-114) |
All odds are correct at the time of publication and are subject to change.
St. John's vs. DePaul picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +7.5 | -125 |
| Moneyline | St. John's | -380 |
| Total | Over 127.5 | -114 |
According to our best women's college basketball bets, the top play to make on this game is Over 127.5 total points.
St. John's vs. DePaul game-day updates and essential details
Tuesday's women's basketball game between DePaul and St. John's at Wintrust Arena is scheduled to start at 7:00 PM ET.
- Who: St. John's vs. DePaul
- Date: Tuesday, February 10, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Wintrust Arena
Conclusion
We predict St. John's, with a 77% win probability, will likely beat DePaul on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate St. John's vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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