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Southern University vs. South Carolina prediction: South Carolina favored to win women's March Madness First Round matchup [3/21/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Southern University vs South Carolina predictions for college basketball Saturday.
South Carolina will face Southern University in March Madness First Round action at Colonial Life Arena on Saturday, beginning at 1:00 PM ET.
Based on updated simulation results, Dimers' new women's basketball model predicts South Carolina as the most likely winner of the Southern University vs. South Carolina game.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Southern University vs. South Carolina prediction: Who will win and advance to the Second Round?
Using trusted machine learning and data, we have simulated the result of Saturday's NCAAW Tournament matchup between Southern University and South Carolina 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model currently gives South Carolina a 99% chance of defeating Southern University.
According to our model, the 131-point over/under has an equal 50-50 chance of hitting.
Southern University vs. South Carolina odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Southern University | South Carolina |
|---|---|---|
| Spread | +53.5 (-108) | -53.5 (-110) |
| Total | o131 (-112) | u131 (-108) |
All odds are correct at the time of publication and are subject to change.
Southern University vs. South Carolina picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern University +53.5 | -108 |
| Total | Under 131 | -108 |
According to our women's college basketball best bets, the top play to make on this game is Southern University +53.5.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Southern University vs. South Carolina game-day updates and essential details
Saturday's women's basketball action between South Carolina and Southern University at Colonial Life Arena is scheduled to commence at 1:00 PM ET.
- Who: Southern University vs. South Carolina
- Date: Saturday, March 21, 2026
- Time: 1:00 PM ET/10:00AM PT
- Venue: Colonial Life Arena
- March Madness stage: First Round
College basketball betting and fantasy promos and codes
Make the most of Dimers' Southern University vs. South Carolina predictions by exploring the below offers from OG, Bet365, BetMGM, and Thrillzz.
Conclusion
We predict South Carolina, with a 99% win probability, will likely beat Southern University this women's March Madness First Round matchup.
AI and automation have enhanced this article to quickly deliver accurate Southern University vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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