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Southern Illinois vs. Northern Iowa prediction: Northern Iowa favored to win men's college basketball matchup [2/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Southern Illinois vs Northern Iowa predictions for college basketball Saturday.
Northern Iowa will square off with Southern Illinois in men's college basketball action at McLeod Center on Saturday, starting at 6:00 PM ET.
Based on the latest simulation results, Dimers' advanced college basketball model predicts Northern Iowa as the most likely winner of the Southern Illinois vs. Northern Iowa game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern Illinois vs. Northern Iowa prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Southern Illinois and Northern Iowa 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model gives Northern Iowa a 74% chance of beating Southern Illinois. Our predicted final score has Northern Iowa winning 70-64.
According to our model, Southern Illinois (+6.5) has a 51% chance of covering the spread, while the over/under total of 134.5 points has an equal 50-50 chance of hitting.
Southern Illinois vs. Northern Iowa odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Southern Illinois | Northern Iowa |
|---|---|---|
| Spread | +6.5 (-105) | -6.5 (-110) |
| Moneyline | +250 | -285 |
| Total | o134.5 (-110) | u134.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern Illinois vs. Northern Iowa picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Illinois +6.5 | -105 |
| Moneyline | Northern Iowa | -285 |
| Total | Over 134.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Northern Iowa to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Southern Illinois vs. Northern Iowa game-day updates and essential details
Saturday's men's college basketball action between Northern Iowa and Southern Illinois at McLeod Center is scheduled to begin at 6:00 PM ET.
- Who: Southern Illinois vs. Northern Iowa
- Date: Saturday, February 21, 2026
- Time: 6:00 PM ET/3:00PM PT
- Venue: McLeod Center
Conclusion
We predict Northern Iowa, with a 74% win probability, will likely beat Southern Illinois on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Northern Iowa insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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