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Southern Illinois vs. Illinois State prediction: Why Illinois State is favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Southern Illinois vs Illinois State predictions for college football Saturday.
Illinois State and Southern Illinois will clash in Week 13 college football action at Hancock Stadium on Saturday, starting at 1:00PM ET.
Based on the latest simulation results, Dimers' advanced college football model predicts Illinois State as the most likely winner of the Southern Illinois vs. Illinois State game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern Illinois vs. Illinois State prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Southern Illinois vs. Illinois State 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives Illinois State a 61% chance of beating Southern Illinois. Our predicted final score has Illinois State winning 31-26.
According to our model, the bookmakers have got it right, and Southern Illinois and Illinois State each have a 50% chance of covering the spread, while the over/under total of 59.5 points has a 58% chance of going over.
Southern Illinois vs. Illinois State odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Southern Illinois | Illinois State |
|---|---|---|
| Spread | +4.5 (-110) | -4.5 (-110) |
| Moneyline | +170 | -192 |
| Total | o59.5 (-110) | u59.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern Illinois vs. Illinois State picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Illinois +4.5 | -110 |
| Moneyline | Southern Illinois | +170 |
| Total | Over 59.5 | -110 |
According to our college football best bets, the top play to make on this game is Over 59.5 total points.
Southern Illinois vs. Illinois State game-day updates and essential details
Saturday's college football matchup between Illinois State and Southern Illinois at Hancock Stadium is scheduled to begin at 1:00PM ET.
- Who: Southern Illinois vs. Illinois State
- Date: Saturday, November 22, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Hancock Stadium
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Conclusion
We predict Illinois State, with a 61% win probability, will likely beat Southern Illinois on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Illinois State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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