Southern Illinois vs. Illinois State Prediction, Picks and Odds

Southern Illinois vs. Illinois State: Detailed Breakdown

Matchup Overview

• Teams: Southern Illinois vs. Illinois State
• Date: Saturday, November 22, 2025
• Time: 1:00 PM ET
• Venue: Hancock Stadium

Current Betting Odds

• Spread: Illinois State favored at -4.5
• Total (Over/Under): 59.5
• Moneyline Odds: Southern Illinois +170, Illinois State -192

Dimers' Win Probabilities

• Southern Illinois: 39%
• Illinois State: 61%

Dimers' predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is Southern Illinois 27-32 Illinois State.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives Southern Illinois a win probability of 39%, while Illinois State has a win probability of 61%.

Summary

According to our analysis, Illinois State is more likely to beat Southern Illinois in CFB action at Hancock Stadium on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Southern Illinois vs. Illinois State predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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