Ohio State vs. Southern California prediction favors Ohio State to win in college football Week 9 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the result of Ohio State vs. Southern California, forming part of our college football predictions coverage.

Our famous predictive model gives Ohio State a 67.7% chance of defeating Southern California. Our predicted final score has Ohio State winning 28-22. According to our model, Southern California (+6.5) has a 51.4% chance of covering the spread, while the over/under total of 53.5 points has a 54.4% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Ohio State -6.5 (-102) / Southern California +6.5 (+100)
• Moneyline: Ohio State -220, Southern California +212
• Total: Over/Under 53.5 (+133/-138)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern California +6.5 @ 50¢ via Novig
• Moneyline: Southern California @ 32¢ via Novig
• Total: Over 53.5 @ 43¢ via Novig

According to our college football best bets, the top play to make on this game is Over 53.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Southern California and Ohio State at Los Angeles Memorial Coliseum is scheduled to start at 7:30 PM ET.

• Who: Ohio State vs. Southern California
• Date: Saturday, October 31, 2026
• Time: 7:30 PM ET/4:30 PM PT
• Venue: Los Angeles Memorial Coliseum

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Conclusion

We predict Ohio State, with a 67.7% win probability, will likely beat Southern California in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.