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South Dakota vs. Southern Illinois prediction: Southern Illinois favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get South Dakota vs Southern Illinois predictions for college football Saturday.
Southern Illinois and South Dakota will meet in Week 12 college football action at Saluki Stadium on Saturday, with kickoff at 1:00PM ET.
Based on the latest simulation results, Dimers' advanced college football model predicts Southern Illinois as the most likely winner of the South Dakota vs. Southern Illinois game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
South Dakota vs. Southern Illinois prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of South Dakota vs. Southern Illinois 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives Southern Illinois a 56% chance of defeating South Dakota. Our predicted final score has Southern Illinois winning 26-24.
According to our model, South Dakota (+3.5) has a 56% chance of covering the spread, while the 50.5-point over/under has a 53% chance of staying under.
South Dakota vs. Southern Illinois odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | South Dakota | Southern Illinois |
|---|---|---|
| Spread | +3.5 (-110) | -3.5 (-110) |
| Moneyline | +160 | -172 |
| Total | o50.5 (-110) | u50.5 (-110) |
All odds are correct at the time of publication and are subject to change.
South Dakota vs. Southern Illinois picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Dakota +3.5 | -110 |
| Moneyline | South Dakota | +160 |
| Total | Under 50.5 | -110 |
According to our college football best bets, the top play to make on this game is South Dakota to win.
South Dakota vs. Southern Illinois game-day updates and essential details
Saturday's college football action between Southern Illinois and South Dakota at Saluki Stadium is scheduled to commence at 1:00PM ET.
- Who: South Dakota vs. Southern Illinois
- Date: Saturday, November 15, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Saluki Stadium
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To make the most of Saturday's massive day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $200 in bonus bets from a $5 bet — win or lose. Don't miss out!
Conclusion
We predict Southern Illinois, with a 56% win probability, will likely beat South Dakota on Saturday.
AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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