South Dakota vs. Southern Illinois Prediction, Picks and Odds

Our in-depth analysis offers a comprehensive prediction for the South Dakota vs. Southern Illinois NCAAF game on November 15, 2025. Drawing from 10,000 simulations, we provide expert picks, betting odds, and insights.

Start your FREE 3-Day trial of Dimers Pro
FINAL
COLLEGE FOOTBALL
Add this game to My Favorites
FINAL
Add this game to My Favorites
CFB sport icon
COLLEGE FOOTBALL
South Dakota
53
51
Nov 15, 6PM Saluki Stadium
Southern Illinois
Nov 15, 6PM Saluki Stadium
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Bets
Live Probabilities
Spread
Over / Under
Moneyline
South DakotaSDAK
Win %
100%
0%
Southern IllinoisSIU
Win Probability
TEAM1234T
South Dakota
7 7 7 13 53
Southern Illinois
14 10 7 3 51
1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0 1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0
Southern Illinois
South Dakota
End of Game
Last Play

Featured offers

Swipe iconSwipe across to view more offers
logo
FEATURED
New DraftKings Customers: Bet $5, Get $200 in Bonus Bets Instantly
T&Cs apply.
How to claim
logo
RECOMMENDED
Double Your Winnings on your Next 10 Wagers. Up to $25 Max Bet Per Boost
T&Cs apply.
How to claim
logo
NEW PLAYERS
Bet $5, Get $150 in Bonus Bets if your bet wins!
T&Cs apply.
How to claim
logo
RECOMMENDED
Deposit $20, Get $50 in Trading Bonus!
T&Cs apply.
How to claim
logo
LIMITED-TIME
Register with code DIMERS150 to unlock $150 in bonus bets by winning your first $10 bet
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get $350 in Bonus Bets Guaranteed - When You Bet $5 for 7 Days!
T&Cs apply.
How to claim
logo
RECOMMENDED
Use Code DIMERS to Get up to $100 in Bonuses by Trading in Your First 7 Days!
T&Cs apply.
How to claim
logo
TRENDING
Bet $10 Get $365 Win or Lose
T&Cs apply.
How to claim
logo
NEW PLAYERS
Get Up To $250 Back in Bonus Bets If Your First Bet Loses
T&Cs apply.
How to claim

South Dakota vs. Southern Illinois: Detailed Breakdown

Matchup Overview

  • Teams: South Dakota vs. Southern Illinois
  • Date: Saturday, November 15, 2025
  • Time: 1:00 PM ET
  • Venue: Saluki Stadium

Current betting odds

  • Spread: Southern Illinois favored at -3.5
  • Total (Over/Under): 50.5
  • Moneyline Odds: South Dakota +160, Southern Illinois -172

Dimers' win probabilities

  • South Dakota: 44%
  • Southern Illinois: 56%

Dimers' predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is South Dakota 24-27 Southern Illinois.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives South Dakota a win probability of 44%, while Southern Illinois has a win probability of 56%.

Summary

According to our analysis, Southern Illinois is more likely to beat South Dakota in CFB action at Saluki Stadium on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our South Dakota vs. Southern Illinois predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

Explore our expert college football predictions and the best college football bets today for more insights and betting opportunities.

Our in-depth analysis includes college football player props and college football futures, as well as constantly updated college football odds and the latest college football news.