South Dakota vs. Southern Illinois Prediction, Picks and Odds

South Dakota vs. Southern Illinois: Detailed Breakdown

Matchup Overview

• Teams: South Dakota vs. Southern Illinois
• Date: Saturday, November 15, 2025
• Time: 1:00 PM ET
• Venue: Saluki Stadium

Current Betting Odds

• Spread: Southern Illinois favored at -3.5
• Total (Over/Under): 50.5
• Moneyline Odds: South Dakota +160, Southern Illinois -172

Dimers' Win Probabilities

• South Dakota: 44%
• Southern Illinois: 56%

Dimers' predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is South Dakota 24-27 Southern Illinois.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives South Dakota a win probability of 44%, while Southern Illinois has a win probability of 56%.

Summary

According to our analysis, Southern Illinois is more likely to beat South Dakota in CFB action at Saluki Stadium on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our South Dakota vs. Southern Illinois predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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