Santa Clara vs. San Francisco prediction: Santa Clara favored to win men's college basketball matchup [2/21/2026]

San Francisco and Santa Clara will meet in men's college basketball action at War Memorial at the Sobrato Center on Saturday, starting at 10:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Santa Clara as the most likely winner of the Santa Clara vs. San Francisco game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Santa Clara vs. San Francisco prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball matchup between Santa Clara and San Francisco 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Santa Clara a 71% chance of beating San Francisco. Our predicted final score has Santa Clara winning 81-75.

According to our model, San Francisco (+6.5) has a 52% chance of covering the spread, while the 159.5-point over/under has a 52% chance of staying under.

Santa Clara vs. San Francisco odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Santa Clara vs. San Francisco picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is San Francisco to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Santa Clara vs. San Francisco game-day updates and essential details

Saturday's men's college basketball game between San Francisco and Santa Clara at War Memorial at the Sobrato Center is scheduled to begin at 10:00 PM ET.

• Who: Santa Clara vs. San Francisco
• Date: Saturday, February 21, 2026
• Time: 10:00 PM ET/7:00PM PT
• Venue: War Memorial at the Sobrato Center

Conclusion

We predict Santa Clara, with a 71% win probability, will likely beat San Francisco on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Santa Clara vs. San Francisco insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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