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49ers vs. Seahawks prediction: Seattle favored to win Divisional Round game [2026]

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Written by Jason Bevilacqua

Get San Francisco 49ers vs Seattle Seahawks predictions for NFL Saturday.

San Francisco 49ers-Seattle Seahawks Predictions and Game Preview.
San Francisco 49ers vs. Seattle Seahawks NFL prediction for Saturday, January 17, 2026.

The Seattle Seahawks and San Francisco 49ers are scheduled to meet in the Divisional Round of the NFL Playoffs at Lumen Field on Saturday, with kickoff at 8:00 PM ET.

Based on updated simulation results, Dimers' proven NFL model projects the Seahawks as the most likely winner of the 49ers vs. Seahawks game.

This article offers a closer look at this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Niners vs. Seahawks prediction: Who will win and cover?

Since our 49ers-Seahawks predictions earlier in the week, we have simulated the result of Saturday's NFL game between the 49ers and Seahawks 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Seahawks a 74% chance of beating the 49ers. Our predicted final score has the Seahawks winning 25-19.

According to our model, the bookmakers have got it right, and the 49ers and Seahawks each have a 50% chance of covering the spread, while the over/under total of 45.5 points also has an equal 50-50 chance of hitting.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 20 straight up picks.

49ers vs. Seahawks odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type 49ers Seahawks
Spread +7 (-105) -7 (-115)
Moneyline +275 -325
Total o45.5 (-102) u45.5 (-118)

All odds are correct at the time of publication and are subject to change.

49ers vs. Seahawks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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